Comparison 7. Subgroup analysis: frequency of administration (HIF versus ESA).

Outcome or subgroup title	No. of studies	No. of participants	Statistical method	Effect size
7.1 Proportion reaching target haemoglobin	14	4601	Risk Ratio (M‐H, Random, 95% CI)	1.00 [0.93, 1.07]
7.1.1 Once a day	7	1315	Risk Ratio (M‐H, Random, 95% CI)	0.97 [0.88, 1.06]
7.1.2 Three times a week	7	3286	Risk Ratio (M‐H, Random, 95% CI)	1.02 [0.93, 1.12]
7.2 Thrombosis	11	17026	Risk Ratio (M‐H, Random, 95% CI)	1.09 [0.86, 1.39]
7.2.1 Once daily	7	14532	Risk Ratio (M‐H, Random, 95% CI)	0.99 [0.71, 1.37]
7.2.2 Three times a week	4	2494	Risk Ratio (M‐H, Random, 95% CI)	1.35 [0.99, 1.83]