Figure 2.

Oxygen consumption of mitochondria isolated from wild-type and KGDHc subunit heterozygote KO mice respiring on succinate in the absence (B) or presence (C,D) of ADP, and after addition of carboxyatractyloside (CAT), (E). (A) Trace is representative of a single experiment. Succinate (5 mM), ADP (2 mM); (C–E) and CAT (2 µM); (E) were given as indicated. All other conditions and representations are as in Figure 1.