TABLE 5.

Effects of opioid receptor antagonists on tonic luteinizing hormone (LH) secretion in pre-pubertal female mammals.

Antagonist	Receptors	Treatment routes	Effects	Species	Ovarian states	References
Naloxone	μ- > κ- >> δ-	s.c.	Stimulatory	Rat	Ovary-intact	Ieiri et al., 1980
		i.v.	Stimulatory	Sheep	Ovary-intact	Ebling et al., 1989
		i.v.	Stimulatory	Sheep	OVX + E2	Ebling et al., 1989
		i.v.	Stimulatory	Sheep	OVX	Ebling et al., 1989
		i.v.	Stimulatory	Sheep	OVX + E2	Wood et al., 1992
nor-BNI	κ-	i.p.	Stimulatory	Rat	Ovary-intact	Nakahara et al., 2013
		i.v.	Stimulatory	Sheep	OVX + E2	Lopez et al., 2016