Table 1.
Biochemical properties of GPXs. AlkylOOH: alkyl hydroperoxide, CumOOH: cumene hydroperoxide, GSH: reduced glutathione, LOOH: lipid hydroperoxide, PCOOH: phoshatidylcholine hydroperoxide, PUFAOOH: polyunsaturated fatty acids hydroperoxide, ROOH: organic hydroperoxide, SeCys: Selenocysteine, TRX: thioredoxin.
| Protein Structure |
Active Site Cys/SeCys | Reducing Agent | Substrate | References | |
|---|---|---|---|---|---|
| Animal GPXs | tetramer, dimer, or monomer | SeCys or Cys | GSH, TRX, NADPH | H2O2, LOOH, ROOH | [11,12] |
| A. thaliana GPXLs | monomer | Cys | TRX | AlkylOOH CumOOH PCOOH PUFAOOH |
[27] |
| GPXs from other plant species | monomer (dimer) |
Cys | TRX, GSH | AlkylOOH CumOOH PCOOH PUFAOOH |
[26,32,52,61,62] |