Table 2.

Main reported functions of relevant GPXs from different mammalian and plant species.

Enzyme		Reported Function/Involvement				Organism	References
		Stress Responses	Redox Regulation/ Signalling	Normal Metabolism	Development
Animal GPXs
	HsGPX1, -2, -3, -5, -6	H2O2 and lipid hydroperoxide processing, stress tolerance	Insulin signalling	H2O2 and lipid hydroperoxide processing +	Male fertility	Homo sapiens	[112]
	HsGPX4	Lipid peroxidation, protein thiol oxidation	Cell death, Ferroptosis	Protein thiol oxidation	Spermatogenesis, chromatin condensation,	Homo sapiens	[23,24,25]
	HsGPX7	General scavenging of ROS, lipid peroxides Anti-inflammatory	Anti-carcinogenesis			Homo sapiens	[18,21,113]
	MmGPX4	Anti-carcinogenesis	Spermatogenesis		Spermatogenesis, male fertility, embryogenic development	Mus musculus	[20]
A. thaliana GPXLs	AtGPXL1-8	Diverse biotic and abiotic (heat, cold, salt, drought, osmotic and metal) stresses, ferroptosis	Maintenance of redox homeostasis, oxidative signal transducer in ABA and drought stress signalling,	Photosynthesis	Development in whole life cycle (embryogenesis, germination, root, shoot apical meristem, hypocotyl, root system, rosette leaves, flowering, pollen tube growth, fertilization, seed dormancy)	A. thaliana	[33,36,41,53,58,64,67,69,114,115]
GPXs from other plant species	OsGPX1-5	Drought, salt, cold, oxidative stresses	Redox signalling, participation in the interaction between ER stress and redox homeostasis, crosstalk between mitochondria and chloroplast	Photosynthesis and cellular respiration	In development during the whole life cycle (embryogenesis, germination, root-, shoot apical meristem, hypocotyl, root system, seedling development, rosette leaves, inflorescence and silique, pollen tube growth, seed setting, grain filling, seed dormancy)	O. sativa	[16,32,34,39,74,77,87,110]
	SlGPX1-5 (GSHPxle1-5)	Heat stress, cold, light stress	unknown	unknown	unknown	S. lycopersicum	[39,58,116]
	HvGPX1-3	Oxidative stress, salt/osmotic stress, norflurazon, and paraquat resistance	unknown	unknown	unknown	H. vulgare	[43]
	BoGPX1-8	Salinity, cold, waterlogging, and drought	Bn BoGPX genes might contribute to stress responses and hormone signaling pathways	unknown	In development of root, seed, leaf, stem, flower, and silique	B. oleracea	[40]
	BrGPX1-12	Salinity, cold, waterlogging, and drought	BrGPX genes might contribute to stress responses and hormone signaling pathways	unknown	In development of root, seed, leaf, stem, flower, and silique	B. rapa	[40]
	BnGPX1-25	Salinity, cold, waterlogging, and drought	BnGPX genes might contribute to stress responses and hormone signaling pathways	unknown	In development of root, seed, leaf, stem, flower, and silique	B. napus	[40]
	GhGPX1-13	Salt stress, heat, sulphate solution	Importance of GhGPXs in hormone signalling, regulation of redox homeostasis	unknown	In regulation of plant growth and development	G. hirsutum	[54]
	TaGPX1-12	Heat, drought and/or a combination, salt	Possible role of TaGPXs in development and stress response, putative roles in signal transductions	GSH biosynthetic and metabolic processes, DNA metabolic processes	Putative roles in plant growth and development, in leaf developmental stages, roots, stems, spikes, and grain	T. aestivum	[55]
	ZmGPX1-7	Drought, waterlogging	Stress regulation through regulatory elements and splicing mechanisms		Growth, development	Z. mays	[52]