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. 2022 Aug 22;11(8):1625. doi: 10.3390/antiox11081625

Figure 1.

Figure 1

Overview of the study designs to study the effect of antioxidants on low dose exposure to MC-LR with (a) choline deficient high fat diet–induced NAFLD and (b) healthy C57Bl/6J mice. (a) Six-week-old mice were fed on CDHFD for six weeks to induce NAFLD. During weeks 5 and 6, mice were orally gavaged with 100 µg/kg MC-LR every 24 h. Mice in the antioxidant groups were given an I.P. injection of 25 mg/kg pNaKtide once a week (2 doses) or 40 mM NAC in drinking water every day during weeks 5 and 6. (b) In a parallel study the mice were fed a standard diet and gavaged with MC-LR during weeks 5 and 6.