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. 2022 Jul 27;11(8):1466. doi: 10.3390/antiox11081466

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© 2022 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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PLpro alters the expression of pro-inflammatory proteins in epithelial cells. Heatmap representation of semi-quantitative expression of 40 pro-inflammatory cytokines and chemokines by antibody array in Calu-3 (A), Caco-2 (B), and HepG2 cells (C) expressing PLpro compared to their pCMV3 counterpart. (D) Box reporting the list of significantly up- or down-regulated pro-inflammatory proteins in all cell lines after transfection with PLpro (PLpro) compared to empty vector (pCMV3). (E) Venn diagram of commonly altered pro-inflammatory molecules in Calu-3, Caco-2 and HepG2 expressing PLpro. Data are reported as mean of Integrated Density values of two independent experiments repeated at least in duplicate.