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. 2022 Jul 31;11(8):1505. doi: 10.3390/antiox11081505

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© 2022 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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MitoTEMPO improves MtDNA stability and mitochondrial dynamics in the placentas of PE-like model. Pregnant rats were administrated with CBX, CBX combined with mitoTEMPO or saline from GD 7.5 to GD 17.5. The rats were sacrificed on GD 20.5 for collection of blood and placental tissues. (A) the transcriptional levels of the genes that control mtDNA maintenance. Left panel: heatmap of the genes related to mtDNA maintenance in RNA-seq. Right panel: cumulative data of Q-PCR analysis. (B) MTERF2 protein expression level. (C) mtDNA copy number. (D) the mRNA levels of mitochondrial dynamic genes. (E) protein levels of OPA1, Parkin and LC3. Left panel: representative images of Western blotting. Right panel: cumulative data of each protein expression level. * p < 0.05, ** p < 0.01, *** p < 0.001, **** p < 0.0001. Con: control; CBX_M: CBX combined with mitoTEMPO treatment.