Table 2.

Demographic and clinical characteristics of study population (n = 64).

Characteristic	AUD (n = 50)	Healthy controls (n = 14)	P-value
Age Mean ± SD (years)	39.5 ±12.0	25.4 ± 5.5	<0.001
	N (%)	N (%)
Sex			0.195
Male	24 (48%)	4 (28.57%)
Female	26 (52%)	10 (71.43%)
Race			0.079
AA/AI	22(44%)	2 (14.29%)
White	26 (52%)	10 (71.43%)
Asian	2 (4%)	2 (14.29%)
Marital status			0.073
Divorced	8 (16.33%)	0
Married	7 (14.29%)	0
Single	34 (69.39%)	14 (100%)
Mood disorder (SCID IV/5)*
Yes	10/50 (20%)	0	0.101
Anxiety disorder (SCID IV/5)*
Yes	17/50 (34%)	0	0.013
	Mean ±SD
CPRS
BSA	7.8 ± 8.1	1.0 ± 1.6	<0.001
MADRS	10.8 ± 10.8	1.5 ± 2.5	<0.001
PSQI Global Score	8.1 ± 4.4	2.4 ± 1.7	<0.001
Drinking measures
Average drinks per day	8.5 ± 4.8	2.8 ± 1.0	<0.001
Number of heavy drinking days	54.7 ± 28.0	3.9 ± 4.6	<0.001
Number of drinking days	69.1 ± 21.1	21.6 ± 11.7	<0.001
Liver and inflammation biomarker
ALP U/L	67.5 ± 19.0	58.6 ± 12.1	0.104
AST U/L	40.1 ± 52.3	19.0 ± 5.4	0.007
Albumin g/dL	4.3 ± 0.3	4.4 ± 0.2	0.258
Bilirubin direct mg/dL	0.08 ± 0.12	0.00 ± 0.00	<0.001
Bilirubin total mg/dL	0.48 ± 0.29	0.42 ± 0.12	0.23
GGT U/L	69.1 ± 82.5	14.6 ± 5.7	<0.001
PT-INR	0.97 ± 0.07	1.03 ± 0.05	0.01
PT-Auto seconds	13.18 ± 0.73	13.72 ± 0.53	0.011
PTT-Auto seconds	31.0 ± 3.1	32.9 ± 2.7	0.033
ALT U/L	40.1 ± 39.7	15.2 ± 11.1	<0.001
CRP mg/L	1.8 ± 2.2	0.7 ± 0.8	0.004

AA/AI, African American/American Indian; SCID, Structural Clinical Interview for DSM Disorders; CPRS, Clinical pathological rating scale; BSA, Brief scale of anxiety; MADRS, Montgomery-Asberg depression rating scale; TLFB, Time-line Followback; ALP, Alkaline Phosphatase; AST, Aspartate Aminotransferase; GGT, Gamma-glutamyl transferase; PT_INR, Prothrombin Time International Normalized Ratio; PT_Auto, Automated Prothrombin time; PTT_Auto, Automated Partial Thromboplastin Time; ALT, Alanine Transaminase; CRP, C-Reactive Protein. *SCID diagnosis of one or more disorder using the version IV or 5 (depending on the time of enrollment).