Table 3.
Subgroup analyses in patients with pathogenic variants in the four predominant non-syndromic SNHI genes.
| SLC26A4 | GJB2 | MYO15A | OTOF | ||||||
|---|---|---|---|---|---|---|---|---|---|
| N = 36 | N = 22 | N = 10 | N = 10 | ||||||
| Mean | SD | Mean | SD | Mean | SD | Mean | SD | ||
| Number | % | Number | % | Number | % | Number | % | p Value | |
| OP age, y | 5.4 | 3.7 | 3.8 | 4.1 | 2.9 | 1.1 | 2.4 | 1.3 | <0.001 * |
| Gender | 0.017 | ||||||||
| Female | 17 | 47.2 | 6 | 27.3 | 8 | 80.0 | 2 | 20.0 | |
| Male | 19 | 52.8 | 16 | 72.7 | 2 | 20.0 | 8 | 80.0 | |
| Laterality | 0.070 | ||||||||
| Unilateral | 26 | 72.2 | 9 | 40.9 | 5 | 50.0 | 4 | 40.0 | |
| Bilateral | 10 | 27.8 | 13 | 59.1 | 5 | 50.0 | 6 | 60.0 | |
| F/U months | 31.2 | 27.4 | 29.3 | 17.1 | 17.9 | 11.5 | 24.1 | 18.9 | 0.274 |
| CAP | 6.0 | 1.5 | 5.7 | 1.8 | 6.1 | 1.0 | 6.2 | 0.8 | 0.891 |
| SIR | 4.4 | 1.3 | 3.6 | 1.5 | 4.2 | 1.3 | 3.7 | 0.9 | 0.081 |
* GJB2 = MYO15A = OTOF < SLC26A4; Abbreviations: CAP, Categories of Auditory Performance; F/U, follow up; SIR, Speech Intelligibility Rating; y, years old.