Figure 3.

The cardiac protection of celastrol. Celastrol exhibits beneficial effects on adverse cardiac remodelling and post-ischemic protection, mainly attributable to its anti-oxidative and anti-inflammatory capacity outlined in the main text. AKT—protein kinase B; Bsg—basigin; CyPA—Cyclophilin A; ERK—extracellular signal-regulated kinases; HMGB1—high mobility group box protein 1; HMOX-1—haem oxygenase-1; HSF1—Heat shock factor 1; HSR—heat shock response; mPTP—mitochondrial permeability transition pore; NF-κB—nuclear factor-κB; ROCK—RhoA/Rho-kinase; ROS—reactive oxygen species; STAT3—Signal transducer and activator of transcription 3; TGF-β—transforming growth factor β. Green arrow indicates “increase”, red arrow indicates “decrease”.