Fig. 6.

Inactivated Wnt/β-catenin pathway arrests the malignant phenotypes and glycolysis of GAC cells. A, Western blot analysis of the Wnt/β-catenin pathway-related proteins in GC9811-P cells upon transduction of si-β-catenin. B, Viability of GC9811-P cells upon silencing of β-catenin measured by CCK-8 assay. C, The number of migrated and invaded GC9811-P cells upon silencing of β-catenin measured by Transwell assay. D, Glucose uptake, and production of lactate and ATP in GC9811-P cells upon silencing of β-catenin. * p < 0.05, compared with si-NC-treated GC9811-P cells. The cell experiment was conducted three times independently.