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. 2022 Aug 17;25:101479. doi: 10.1016/j.tranon.2022.101479

Fig. 7.

Fig 7

Exosomal circ_0038138 boosts glycolysis, tumorigenesis and lung metastasis of GAC cells by regulating the miR-198/EZH2 axis in vivo. A, miR-198 expression and mRNA expression of CXXC4, circ_0038138 and EZH2 in tumor tissues of GC9811-P-Exo-treated mice. B, Western blot analysis of expression of EZH2, CXXC4 and β-catenin proteins along with p-GSK-3β extent in tumor tissues of GC9811-P-Exo-treated mice. C, Representative images showing xenografts in GC9811-P-Exo-treated mice at 7 week. D, Tumor weight of GC9811-P-Exo-treated mice at 7 week. E, Glucose uptake, and production of lactate and ATP in tumor tissues of GC9811-P-Exo-treated mice. F, The number of metastatic nodes in the tumor tissues of GC9811-P-Exo-treated mice. * p < 0.05, compared with mice treated with PBS. n = 10 for mice following each treatment.