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. 2022 Aug 17;11(8):1225. doi: 10.3390/biology11081225

Table 3.

Indirect effects of TAM via Foxp3 knockout model.

Immune System Involve Specific Cells and Other Immune Checkpoints References
Adaptive Foxp3+ Treg
  • -

    Developing Foxp3 knockout model.

  • -

    Allowing nuclear translocation of the fusion protein, excision of the floxed STOP cassette and constitutive and heritable expression of YFP in a cohort of cells that express Foxp3.

 [43,54]
CTLA4
  • -

    Act as a biological rheostat on conventional dendritic cells (cDC) by controlling the engagement with costimulatory proteins CD80 and CD86 via CTLA-4 or CD28.

 [30]
PD-1
  • -

    Immune suppression of Tregs via the reduced signaling of PI3K–AKT pathway as a mechanism.

 [68]
LAG-3
  • -

    Allows T cells to regain their cytotoxic function and potentially inhibit tumor growth.

 [77]
TIM3
  • -

    Enhances antitumor immunity, with increased expression of interleukin-10 (IL-10) and a shift to a more glycolytic metabolic phenotype.

 [53]