Table 5.
Liver function parameters at baseline, 6 weeks and post-intervention in the placebo and PMBE groups.
| Time | Reference Intervals 1 | |||
|---|---|---|---|---|
| Outcomes | Baseline | 6-Weeks | 12-Weeks | |
| Calc Glob (g/L) | ||||
| Placebo | 28.73 (0.36) | 28.64 (0.38) | 29.07 (0.42) | 25–35 |
| PMBE | 29.59 (0.50) | 29.68 (0.62) | 29.50 (0.56) | |
| T. Bilirubin (umol/L) | ||||
| Placebo | 10 (8, 12) | 9 (7, 12) | 10 (9, 13) | <20 |
| PMBE | 13 (9, 19) | 12 (11, 20) | 13 (8, 23) | |
| GGT (U/L) | ||||
| Placebo | 16 (13, 21) | 17.5 (13, 24) | 17.5 (13, 26) | <50 (male) |
| PMBE | 18 (13, 24.5) | 17.5 (14, 27) | 17.5 (14. 24) | <30 (female) |
| ALP (U/L) | ||||
| Placebo | 74.10 (2.82) | 77.14 (2.53) | 74.83 (3.15) | 30–110 |
| PMBE | 65.44 (2.62) | 67.95 (3.41) | 68.00 (3.19) * | |
| ALT (U/L) | ||||
| Placebo | 23.5 (20, 32) | 25 (22, 33) | 24 (21, 30) | <35 |
| PMBE | 23 (21, 27.5) | 24.5 (21, 30) | 24.5 (20, 30) | |
| AST (U/L) | ||||
| Placebo | 26 (23, 29) | 26 (24, 29) | 25.5 (24, 29) | <40 |
| PMBE | 25 (23, 30) | 26 (24, 29) | 25 (22, 29) | |
Values are reported as mean (SEM) or median (25th percentile, 75th percentile) depending on distribution of data. Paired t-test was used to compare changes from baseline to post-intervention for normally distributed data and Wilcoxon signed rank test for non-normally distributed data within groups. * p < 0.05. 1 Reference Intervals for Liver Function Tests by The Royal College of Pathologists of Australia (RCPA) [35]. ALP, alkaline phosphatase; ALT, alanine aminotransferase; AST, aspartate transaminase; Calc Glob, calculated globulin; PMBE, Pinus massoniana bark extract; T. Bilirubin, total bilirubin.