Table 2.
Electrophiles which cytotoxicity are or could be prevented by nucleophilic interaction with NAC.
| Electrophilic Moiety |
Structure | Proved Examples | Possible Examples |
|---|---|---|---|
| α,β-unsaturated carbonyls |
|
GDN [55], patulin [64], 18β-glycyrrhetinic acid [69] | Acrolein, Acrylamide, 4-hydroxy-2-nonenal, Henenalin, afatinib |
| Conjugated dienes |
|
Patulin [64], EF-24 [71], hemin [105] | Retinol, callystatin A, trichostatin A |
| Organic isothiocyanates |
|
Phenylethyl isothiocyanate [103,104] | Sulphoraphan, benzyl isothiocyanate |
| Hydrazones |
|
FCCP [70] | CCCP, piperonal ciprofloxacin hydrazone |
| Epoxides |
|
- | Epichlorohydrin, Cantharidin |
| Organic acid anhydrides |
|
- | Cantharidin |