Table 3.
MICs geometric mean and range of the indicated antibiotics as monotherapy and in combination.
| MIC Geometric Mean (Range) (mg/L) | FICI | Interpretation | ||||
|---|---|---|---|---|---|---|
| MICA | MICA (with B) | MICB | MICB (with A) | |||
| GEN and CRO | ||||||
| CRO MIC ≤ 0.125 mg/L (n = 378) |
6.758 (1–32) | 2.320 (1–16) | 0.027 (0.004–0.125) | 0.013 (0.004–0.125) | 0.833 (0.37–4.5) | indifference |
| CRO MIC ≥ 0.25 mg/L (n = 2) |
8 | 4 | 0.25 | 0.03 | 0.62 | indifference |
| GEN and CRO all isolates (n = 380) |
6.764 (1–32) | 2.327 (1–16) | 0.027 (0.008–0.25) | 0.014 (0.004–0.125) | 0.832 (0.370–4.5) | indifference |
| GEN and AZM | ||||||
| AZM MIC ≤ 0.5 mg/L (n = 314) |
6.515 (1–32) | 3.504 (1–16) | 0.143 (0.03–0.5) | 0.052 (0.015–0.25) | 1.004 (0.365–3) | indifference |
| AZM MIC ≥ 1 mg/L (n = 66) |
8.084 (2–32) | 5.367 (1–16) | 2.021 (1–8) | 0.314 (0.06–4) | 0.919 (0.28–3) | indifference |
| GEN + AZM all isolates (n = 380) |
6.764 (1–32) | 3.773 (1–16) | 0.226 (0.03–8) | 0.072 (0.015–4) | 0.987 (0.280–3) | indifference |
| AZM and CRO all isolates (n = 380) |
0.226 (0.03–8) | 0.1 (0.015–4) | 0.027 (0.008–0.25) | 0.017 (0.004–0.25) | 0.874 (0.280–6.167) | indifference |