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Novel reconstructed proteins induced human macrophages to phagocytize MDA-MB-231 tumor cells. The proportion of macrophages that engulfed tumor cells was measured by flow cytometry as a proportion of CFSE+CD11b+ cells. (A) Isotype IgG1; (B) positive control anti-CD47 mAb; (C) structure control CV1-Fc; (D) prototype IAI (E) Pro1; (F) Pro2; (G) Pro3. (H) The results are presented as mean ± standard deviation (SD), where * p < 0.05 is indicative of statistical difference.
