Figure 1.
Upregulation of NOX1, NOX2, NOX4, and NOX5 in lung tissue sections of patients with end-stage COPD. Lung tissue sections of end-stage COPD patients and non-smoking donor controls were subjected to immunohistochemical staining using antibodies for NOX1, NOX2, NOX4, or NOX5. The representative images are shown in panels (A,C,E,G), while the grouped data are shown in panels (B,D,F,H). The data indicate that the protein expression levels of NOX1, NOX2, NOX4, and NOX5 were significantly upregulated in end-stage COPD patients compared to donor controls. All data are presented as Mean ± SEM, n = 6–18. Scale bar, 50 µm. * p < 0.05; ** p < 0.01 vs. donor control group.