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. 2022 Aug 19;11(8):1608. doi: 10.3390/antiox11081608

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© 2022 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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Molecular characterization of preeclampsia. Gene expressions of (A) sFlt1 and (B) PlGF as well as (C) sFlt1/PlGF mRNA ratios in the placentas of NP and PE-19 rats. (D) The sFlt1/PlGF ratio was measured by immunoassay in placental homogenates. (E–G) Similar experiments as in (A–C) were performed in the kidney, including an additional (PE-11) preeclamptic group. (H,I) sFlt1 protein expressions and (J,K) endoglin gene expressions in placenta and kidney, respectively. The quantitative fold changes in gene expressions were determined relative to GAPDH in each corresponding group. Values are expressed as mean ± SEM of at least six animals per group: ** p < 0.01, *** p < 0.001 vs. NP; ^### p < 0.001 vs. PE-11. NP: normal pregnant rats; PE-11: preeclamptic rats at GD11; PE-19: preeclamptic rats at GD19.