Figure 1.

Effect of ARNI and ivabradine on systolic blood pressure (SBP) (A) and heart rate (HR) (B) throughout the experiment, and the relative weight of the left ventricle (left ventricular weight/body weight; LVW/BW) (C) in SHRs after six weeks of treatment. ARNI, sacubitril/valsartan; C, Wistar controls; IVA, ivabradine; SHRs, spontaneously hypertensive rats. Results are presented as means ± SEM. n = 15 per group. Repeated measures ANOVA (A,B) or one-way, two-tailed ANOVA (C) followed by multiple comparisons with a Bonferroni post-hoc test; * p < 0.05 vs. C; # p < 0.05 vs. SHR.