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Schematic depicting the serum angiotensin and aldosterone concentrations in the study groups after six weeks of treatment. Results are presented as means. ACE, angiotensin-converting enzyme; Aldo, aldosterone; Ang, angiotensin; AP, aminopeptidase; ARNI, sacubitril/valsartan; AT1R, angiotensin II type 1 receptor; NEP, neprilysin (neutral endopeptidase); SHRs, spontaneously hypertensive rats. n = 6 per group.
