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. 2022 Jul 31;10(8):1844. doi: 10.3390/biomedicines10081844

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© 2022 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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Effect of ARNI and ivabradine on left ventricular ejection fraction (LVEF) (A), left ventricular fractional shortening (LVFS) (B), the ratio of the diastolic transmitral peak early and late filling velocities (E/A ratio) (C), and the ratio of the diastolic transmitral peak early filling velocity and the maximal velocity of early diastolic wall movement wave at the level of mitral annulus (E/Em ratio) (D) in SHRs after six weeks of treatment. ARNI, sacubitril/valsartan; C, Wistar controls; IVA, ivabradine; SHRs, spontaneously hypertensive rats. Results are presented as means ± SEM. n = 7 per group. One-way, two-tailed ANOVA followed by multiple comparisons with a Bonferroni post-hoc test; * p < 0.05 vs. C; # p < 0.05 vs. SHR.