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. 2022 Aug 11;15:979479. doi: 10.3389/fnmol.2022.979479

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Copyright © 2022 Vazetdinova, Valiullina-Rakhmatullina, Rozov, Evstifeev, Khazipov and Nasretdinov.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Cell-attached recordings of GABAergic postsynaptic responses in the neonatal hippocampus. (A) Scheme of the experimental setup. GABA-PSPs are evoked by electrical stimulation in the presence of the ionotropic glutamate antagonists CNQX (10 μM) and d-APV (40 μM) in a neonatal mouse hippocampal slice. Responses were recorded from CA3 pyramidal cells in CA/CC configuration without disturbance of intracellular chloride concentration. (B) Average evoked GABA-PSPs in five CA3 pyramidal cells, of which four show depolarizing responses (cells #1–4) and one (cell #5) shows a hyperpolarizing response. Inset shows group data on the amplitude of evoked GABA-PSPs recorded from 9 CA3 pyramidal cells of P6 mouse. (C) Example traces of evoked GABA-PSPs, some of which trigger APs. Below, a corresponding AP peristimulus time histogram.