Figure 7.

Correlation of levels of IgG anti-RG2 strain cell wall lipoglycan antibodies and IgG anti-native DNA autoantibodies correlate with levels of RG colonization induced increased intestinal permeability. Each point represents an individual male and female littermate that had been neonatally colonized with S107-48 RG strain from a GF breeding pair, as depicted in Figures 5, 6B, G, respectively. Results are shown from Spearman correlation analysis. IgG anti-RG2 plasma tested at 1:1000 dilution, and IgG anti-dsDNA was tested at a 1:100 dilution. Samples were studied that were above the 0.22 μg/ml FITC-Dextran (μg/ml) cut-off that was chosen to represent leakiness (i.e., above values in controls)(N=9). Spearman test used, with r and p values shown.