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Neonatal RG colonization causes morphologic intestinal abnormalities and raised tight junction Occludin gene transcript levels. Representative H&E staining of terminal Ileum sections from litters of RG-colonized and control or GF mice, with comparisons of mice sacrificed at 14 weeks of age (n = 4 mice/group). S107-48 RG strain colonized mice, which were previously GF, demonstrate subjective flattening of epithelial villi and reduced goblet cells at bases.
