Table 7.
Registered clinical trials on NAC or GSH supplementation in COVID-19 treatment that are recruiting patients or have been completed.
| Clinical Trial ID Number | Title | Location | Interventions | Status | Study Results |
|---|---|---|---|---|---|
| NCT04703036 | Glutathione, Oxidative Stress and Mitochondrial Function in COVID-19 | United States | Glycine, NAC, alanine | Recruiting | No Results Available |
| NCT04458298 | A Study to Evaluate OP-101 (Dendrimer N-acetyl-cysteine) in Severe Coronavirus Disease 2019 (COVID-19) Patients | United States | OP-101, placebo | Recruiting | No Results Available |
| NCT04573153 | Metabolic Cofactor Supplementation and Hydroxychloroquine Combination in COVID-19 Patients | Turkey | Hydroxychloroquine + metabolic cofactor, hydroxychloroquine + sorbitol | Recruiting | No Results Available |
| NCT04483973 | SPI-1005 Treatment in Severe COVID-19 Patients | United States | Ebselen, placebo | Enrolling by invitation | No Results Available |
| NCT04484025 | SPI-1005 Treatment in Moderate COVID-19 Patients | United States | Ebselen, placebo | Enrolling by invitation | No Results Available |
| NCT04797871 | Resistance Training and Clinical Status in Patients With Post Discharge Symptoms After COVID-19 | Spain | Behavioral: Resistance training, Standard care | Enrolling by invitation | No Results Available |
| NCT04569851 | Clinical Characteristics and Prognostic Factors of Patients With COVID-19 (Coronavirus Disease 2019) | Spain | NA | Enrolling by invitation | No Results Available |
| NCT04742725 | A Study to Evaluate the Efficacy and Safety of Prothione Capsules for Mild to Moderate COVID-19 | Rwanda | Prothione, placebo | Completed | No Results Available |
| NCT04792021 | Effect of N-acetylcysteine on Oxidative Stress in COVID-19 Patients | Egypt | NAC | Completed | No Results Available |
| NCT04419025 | Efficacy of N-Acetylcysteine (NAC) in Preventing COVID-19 From Progressing to Severe Disease | United States | NAC | Completed | No Results Available |
| NCT04900129 | Inhalation of Vapor With Medication (Diclofenac Sodium, Menthol, Methyl Salicylate and N-Acetyl Cysteine) Reduces Oxygen Need and Hospital Stay in COVID-19 Patients—A Case Control Study | Bangladesh | Combination of menthol, methyl salicylate, NAC and diclofenac sodium | Completed | No Results Available |
| NCT04570254 | Antioxidants as Adjuvant Therapy to Standard Therapy in Patients With COVID-19 | Mexico | Vitamin C, vitamin E, melatonin, NAC, pentoxifylline | Completed | No Results Available |
| NCT04755972 | Mucolytics in Patients on Invasive Mechanical Ventilation Due to Severe Acute Respiratory Syndrome Coronavirus 2 | Croatia | Inhalation of NAC, inhalation of sodium chloride, inhalation of sodium bicarbonate | Completed | No Results Available |
| NCT04666753 | Retrospective Study of ImmunoFormulation for COVID-19 | Spain | ImmunoFormulation | Completed | No Results Available |
NAC: N-Acetylcysteine, NA: not available.