Figure 5.

Assessment of locomotor activity in the open field. Rats were submitted to a PTZ-kindling protocol with or without chronic cannabidiol (60 mg/kg body weight) administration (mean ± SEM, n = 18). (a) The number of entries in the center zone; (b) time spent in the central zone of the arena, defined as a 30 × 30 cm square out of an 60 × 60 cm total surface of the arena; (c) the vertical exploration of the animals was expressed as the time spent leaning on the walls of the arena; (d) total distance moved during the 5 min testing session. CBD, cannabidiol. Data are expressed as mean ± SEM (n = 7–11) for each parameter.