Figure 6.

The effects of chronic CBD (60 mg/kg body weight) treatment on cognitive performance of rats subjected to a PTZ-kindling protocol. (a) Discrimination index (DI), which shows the discrimination between the novel and familiar objects, i.e., the difference in exploration time for a familiar object, but then dividing this value by the total amount of exploration of the novel and familiar objects [DI = (TN − TF)/(TN + TF)] showed a significant decrease in the CBD-treated group. + sign shows the arithmetic mean, whereas the line represents the median; (b) the total exploration time of the arena (mean ± SEM) did not show statistically significant difference between groups; (c) the total exploration time of the objects (mean ± SEM) was also similar for both groups; (d) the total distance moved by both groups (mean ± SEM) during the 5 min testing session was almost equal, and the results were similar to those found in the OF test. CBD, cannabidiol; * p < 0.05 vs. control. Data are expressed as mean ± SEM (n = 7–11) for each parameter.