TABLE 1.

Redox modulation by cytotoxic anticancer drugs currently used clinically (Chen and Chang, 2019).

Target	Drug	Mechanism of redox modulation
Glutathione system	NOV-002	Induction of S-glutathionylation
	BSO	Glutathione depletion leading to induction of apoptosis by ROS
	TLK286	Inhibition of glutathione-S-transferase
	TLK199	Inhibition of glutathione-S-transferase
Thioredoxin system	PX-12	Inhibition of thioredoxin-1
	BNP7787	Inhibition of thioredoxin-1 and glutaredoxin
Arsenic derivatives	ZIO-101	Inhibition of catalase