Figure 18.

Upstream regulators of differential gene expression caused by Arc knockdown. The map shows 11 upstream regulators (blue and orange boxes) predicted by IPA to mediate altered gene expression upon Arc knockdown. Genes are positioned in the extracellular space, the plasma membrane, the cytosol, or the nucleus, depending on where their associated proteins are located. Arc was positioned at the interface of nucleus and cytoplasm because it can be in either compartment. Only genes that were involved in the following pathways and disease annotations are shown: (i) opioid signalling, (ii) synaptogenesis, (iii) endocannabinoid neuronal synapse pathway, (iv) synaptic LTD, (v) neuroinflammation, (vi) CNS amyloidosis, (vii) tauopathy and (viii) AD. Genes associated with disease annotations are boxed in magenta. The respective fold changes are indicated below each gene.