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. 2022 Aug 21;10(8):2045. doi: 10.3390/biomedicines10082045
AE Adverse Event
AUC Area below the Serum Concentration Curve
AUCO-t Last Time Point
BC Breast Cancer
CHR Complete Histological Response
CI Confidence Intervals
Cmax Maximum Measured Concentration
Ctrough Concentration Trough Plasma Levels
DFS Disease-Free Survival
EBC Early Breast Cancer
EFS Event-Free Survival
EGFR Epidermal Growth Factor Receptor
EMA The European Medicines Agency
FcγRIIIa FcγR IIIa Receptor
FDA The United States Food and Drug Administration Agency
FDP Free Disease Progression
FEC Fluorouracil, Epirubicin, Cyclophosphamide
HER2+ HER2-positive
HER+ EBC HER+ Early BC
HER2+ MBC HER+ Metastatic BC
IVT-mRNA In Vitro-Transcribed mRNA
MAPK Mitogen-Activated Protein Kinase Pathway
MKI67 Ki-67 Cell Proliferation Index
MBC Metastatic Breast Cancer
OS Overall Survival
OR Overall Response
ORR Objective Response Rate
pCR Pathological Complete Response
PFS Progression-Free Survival
PLCγ Phospholipase Cγ
PI3K Phosphatidylinositol 3-kinase Pathway
PR Partial Response
SAE Serious Adverse Event
TEAE Treatment-Emergent Adverse Events
TTD Time to Treatment Discontinuation
TRZ Trastuzumab