Table 1.
Demographic features, clinical data, respiratory functional parameters and radiological pattern of the entire study population and among the three subgroups. * Post test comparison between PF-ILD and IPF; ° post test comparison between FPF and IPF patients.
| Parameters | Study Population | IPF | PF-ILD | FPF |
p-Value (Mean Difference; CI 95%) |
|---|---|---|---|---|---|
| N° | 197 | 150 | 30 | 17 | p = 0.0019 * (6.305; 2.152–10.46) |
| Age (yrs) | 72.6 ± 8.1 | 74.4 ± 8.2 | 68.1 ± 9.6 | 70.3 ± 7.7 | p = 0.1579 ° (4.126; −2.117–11.22) |
| Male gender (%) | 145 | 117 (78) | 17 (56.6) | 11 (64.7) | p = 0.0092 * (Chi-square: 9.372) |
| p = 0.0957 ° (Chi-square: 9.372) | |||||
| Pack/year | 28.3 ± 15 | 27.2 ± 14.7 | 30.6 ± 17.3 | 25.1 ±17.5 | p = 0.1869 |
| Comorbidities | |||||
| Hypertension | 81 | 66 | 10 | 5 | p = 0.3283 |
| GERD | 33 | 25 | 5 | 3 | p = 0.9947 |
| Ischemic heart disease | 45 | 33 | 9 | 3 | p = 0.5508 |
| Cancer | 14 | 10 | 3 | 1 | p = 0.8874 |
| Diabetes mellitus | 33 | 22 | 7 | 4 | p = 0.3754 |
| Osteoporosis | 35 | 25 | 6 | 4 | p = 0.7360 |
| HRCT pattern | |||||
| UIP | 121 | 105 | 6 | 10 | p = 0.00004 (Chi-square: 44.77) |
| Probable UIP | 41 | 40 | 1 | 0 | |
| Indeterminate for UIP | 14 | 5 | 4 | 5 | |
| Not UIP | 21 | 0 | 19 | 2 | |
| Baseline PFTs | |||||
| FVC (l) | 2.3 ± 0.7 | 2.4 ± 0.7 | 2.2 ± 0.7 | 2.1 ± 0.9 | p = 0.0657 |
| FVC (%) | 74.2 ± 19.7 | 74.9 ± 18.9 | 71.7 ± 20.6 | 73 ± 22.1 | p = 0.2817 |
| FEV1 (l) | 1.8 ± 0.5 | 1.9 ± 0.5 | 1.8 ± 0.5 | 1.7 ± 0.6 | p = 0.0867 |
| FEV1 (%) | 77.5 ± 20 | 78.6 ± 19 | 75.6 ± 20.8 | 75.3 ± 24.1 | p = 0.3258 |
| TLC (l) | 4.3 ± 1.1 | 4.4 ± 1.2 | 4.1 ± 0.8 | 4 ± 1.1 | p = 0.0783 |
| TLC (%) | 71.2 ± 11.1 | 73.6 ± 17.2 | 68.8 ± 12.6 | 69.5 ± 8.5 | p = 0.1597 |
| DLCO (%) | 42.7 ± 17.3 | 41.4 ± 17.9 | 47.6 ± 17.5 | 40.5 ± 15.6 | p = 0.1357 |
| DLCO/AV (%) | 71.2 ± 23.5 | 68.7 ± 22.3 | 72.8 ± 15.6 | 69.7 ± 16.5 | p = 0.3359 |
| ΔFVC ml pre-treatment | (−256) ± 352 | (−270) ± 393 | (−238) ± 320.8 | (−268) ± 224.5 | p = 0.9486 |
| ΔFVC % pre-treatment | (−8.8) ± 11.3 | (−9.1) ± 12 | (−7.7) ± 9.3 | (−12.5) ± 11.5 | p = 0.6589 |
| ΔDLCO % pre-treatment | (−7.5) ± 15.7 | (−7.7) ±15.1 | (−5.6) ± 18.5 | (−8.5) ± 12.5 | p = 0.8853 |
AV: alveolar volume; DLCO: diffusion lung capacity for carbon monoxide; FEV1: forced expiratory volume in the first second; FVC: forced vital capacity; GERD: gastroesophageal reflux disease; HRCT: high resolution computed tomography; PFT: pulmonary function test; TLC: total lung capacity; UIP: usual interstitial pneumonia.