Table 3.
Univariate and multivariate analysis for progression-free survival in the entire study population.
| Covariates | B | SE | p-Value | HR (95% CI) |
|---|---|---|---|---|
| Univariate analysis | ||||
| Age | −0.006 | 0.014 | 0.651 | 0.99 (0.96–1.02) |
| Female gender | −0.500 | 0.257 | 0.025 | 0.60 (0.36–1.01) |
| Time from onset to diagnosis | −0.005 | 0.004 | 0.225 | 0.99 (0.98–1.01) |
| Diagnosis of FPF | 0.990 | 0.310 | 0.005 | 2.69 (1.2–6.3) |
| FVC > 70% | −0.392 | 0.242 | 0.030 | 0.67 (0.32–0.97) |
| DLCO > 50% | −0.159 | 0.279 | 0.568 | 0.85 (0.49–1.47) |
| paO2/FiO2 > 300 | −0.719 | 0.455 | 0.114 | 0.48 (0.20–1.18) |
| SpO2 > 90% during 6MWT | −0.178 | 0.364 | 0.625 | 0.83 (0.41–1.70) |
| UIP pattern at HRCT | 0.115 | 0.195 | 0.277 | 1.2 (0.72–1.65) |
| Multivariate analysis | ||||
| Age | −0.005 | 0.017 | 0.778 | 0.99 (0.96–1.02) |
| Female gender | −0.494 | 0.312 | 0.113 | 0.61 (0.33–1.12) |
| FVC > 70% | −0.361 | 0.266 | 0.175 | 0.63 (0.34–1.34) |
| Diagnosis of FPF | 1.234 | 0.588 | 0.036 | 3.43 (1.08–10.87) |
6MWT: 6-min walking test; DLCO: diffusion lung capacity for carbon monoxide; FiO2: fraction of inspired oxygen; FVC: forced vital capacity; HRCT: high resolution computed tomography; FPF: familial pulmonary fibrosis; paO2: arterial partial pressure of oxygen; SpO2: peripheral oxygen saturation; UIP: usual interstitial pneumonia.