Table 3.
Peripheral biomarkers of CNS function.
| Participants | Study design | Article | |
|---|---|---|---|
| Biomarker of: | |||
| ↗ abstinence: ↘ BDNF levels | N = 40 | Prospective | Corominas-Roso et al., 2015 [15] |
| ↘ abstinence: ↗ BDNF levels | N = 35 | Prospective | D’Sa et al., 2011 [53] |
| ↗ abstinence: ↗ BDNF levels | N = 22 | Cross-sectional | Hilburn et al., 2011 [54] |
| ↗ abstinence: ↘ BDNF levels between entry and 2 weeks of detoxification | N = 31 | Prospective | Hirsch et al., 2018 [55] |
| ↗ severity of CUD: ↗ n-methylserotonin levels, ↘ xanthine levels | N = 18 | Cross-sectional | Patkar et al., 2009 [56] |
| ↗ abstinence: ↗ BDNF levels | N = 47 | Prospective | Scherer et al., 2016 [57] |
| ↗ severity of CUD: ↘ BDNF levels | N = 49 | Prospective | Sordi et al., 2014 [58] |
↘: decreased, ↗: increased, BDNF: Brain-Derived Neurotrophic Factor, CUD: cocaine use disorder.