Figure 11.

Schematic representation of the SERS-based LFA. (a) When the A(H1N1) was present in the sample solution, the SERS-virus complexes were formed and captured by the test line anti-bodies; excess SERS nanoprobes continued to flow and were captured by antibodies in the control line. In this scenario, the buildup of AuNPs causes both the control and test lines to turn red (left, positive). If the fluid contains no viruses, just the control line goes reddish (negative, right). (b) The associated SERS-virus nanoprobe complexes produced a SERS spectrum (top), but no signal was produced in the absence of the virus (bottom). Reproduced with permission from ref. [95]. Copyright 2016 John Wiley & Sons, Inc.