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. 2022 Aug 18;10(8):2009. doi: 10.3390/biomedicines10082009

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© 2022 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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(A) Chromatographic profile acquired by UHPLC-PDA (λ = 280 nm) of phytochemical compounds in cocoa ethanolic extract. Identified peaks are: fraction I: (1) Theobromine; fraction II: (2) Catechin-3-O-hexoside; (3) N-Caffeoyl-L-aspartate; fraction III: (4) Procyanidin B-type; (5) Epicatechin; (6) Procyanidin B-type trimer; (7) Procyanidin B-type tetramer; (8) Procyanidin B-type tetramer (isomer); (9) Procyanidin B-type pentamer; (10) Procyanidin B-type hexamer; (11) Procyanidin A-type hexoside; (12) Quercetin 3-O- arabinoside. (B) Main components of the cocoa fractions. (C) PB assay showed the neuroprotective effect of fraction III against 6-OHDA-induced cytotoxicity. (D,E) Effect of fraction III on PERK and eif2α phosphorylation. Results are showed as mean ± standard deviation (SD) from three independent experiments. ### denotes p < 0.001 vs. Ctrl; **, *** denote respectively p < 0.01 and p < 0.001 vs. 6-OHDA.