Table 2.

Differentially expressed genes (DEGs) up and downregulated involved in “Fatty acid metabolic process”, “Lipid metabolic process” and “Carbohydrate metabolic process”.

Biological Process	Upregulated DEGs	Fold Change	Downregulated DEGs	Fold Change
Fatty acid metabolic process	ABCD4	0.72	ACAT1	−1.13
	ACOT8	1.44	ACSL1	−1.93
	ACSF3	1.48	AKR1C4	−3.73
	CPT1A	0.62	CRAT	−0.28
	CRYL1	0.69	DBI	−1.85
	GSTM1	7.35	DECR1	−1.61
	TNXB	1.24	ETFDH	−1.15
			HADHA	−0.67
			HSD17B4	−1.14
			PPARG	−1.2
			PRKAA2	−5.69
			SNCA	−0.81
Lipid metabolic process	ABCD4	0.72	ACAT1	−1.13
	ACOT8	1.44	ACOT13	−1.87
	ACSF3	1.48	ACSL1	−1.93
	AGPAT1	0.56	AKR1C4	−3.73
	ARSA	1.82	ATF2	−0.76
	CPNE1	1.05	CERT1	−0.54
	CPT1A	0.62	CRAT	−0.28
	CRYL1	0.69	DBI	−1.85
	CSF1R	1.06	DECR1	−1.61
	CYP27A1	1.89	DHRS4	−0.91
	DGKD	0.59	DPM1	−0.68
	FDXR	4.13	ETFDH	−1.15
	GGT7	0.94	FGF2	−0.81
	GSTM1	7.35	HADHA	−0.67
	HSPG2	0.72	HSD17B4	−1.14
	ITGB8	2.50	INSIG1	−2.00
	LPCAT1	0.73	LDAH	−0.75
	LRP10	1.13	MBTPS1	−0.54
	LRP2	21.33	MTMR12	−0.77
	OSBPL3	1.13	MTMR6	−0.53
	PDGFRB	1.04	OSBPL1A	−0.49
	PGAP3	1.82	PAFAH1B2	−0.57
	PIGO	0.91	PIK3C3	−0.90
	PIP5K1C	1.21	PPARG	−1.20
	PLCD1	0.93	PRKAA2	−5.69
	PLCG2	0.85	PTPN11	−1.01
	PLTP	1.81	SNCA	−0.81
	PNPLA6	1.14
	PNPLA7	2.11
	PRKD2	1.18
	SPTLC2	0.65
	TNXB	1.24
Carbohydrate metabolic process	AMDHD2	1.58	HK1	−0.79
	BRAT1	2.01	ST6GALNAC1	−3.85
	CPT1A	0.62	UGP2	−0.81
	GAA	1.23
	MAN1B1	1.06
	SPATA20	0.68

DEGs involved in “Fatty acid metabolic process”, “Lipid metabolic process” and “Carbohydrate metabolic process” with fold change associated. Fold change was calculated as log₂ (AT-OB/AT-Ctrl). In this line, the upregulated genes were more expressed in AT-OB, while downregulated genes were more expressed in AT-Ctrl. All the values are rounded to the second decimal digit.