Table 4.

Differentially expressed genes (DEGs) up and downregulated involved in the “Inflammatory response” and its regulation.

Biological Process	Upregulated DEGs	Fold Change	Downregulated DEGs	Fold Change
Inflammatory response	AFAP1L2	1.08	AP3B1	−0.51
	BMP6	1.71	ASS1	−0.73
	CARD8	0.74	HK1	−0.79
	CD14	1.94	IFNGR1	−0.96
	CIITA	1.28	MS4A2	−3.52
	CSF1R	1.06	SNCA	−0.81
	CYBA	0.94
	EPHA2	2.26
	FFAR3	3.47
	GRN	0.78
	GSDMD	1.44
	HDAC4	1.11
	HNRNPA0	0.98
	HSPG2	0.72
	IGFBP4	1.95
	IKBKB	0.91
	KDM6B	1.84
	LGALS9	0.71
	LOXL3	1.07
	MFHAS1	1.44
	NFATC4	2.05
	NFKBID	3.03
	NLRP1	1.71
	PTGDR	1.41
	RPS6KA4	1.84
	SIGLEC1	1.30
	SMO	2.17
	STAB1	1.50
	TCIRG1	1.67
	THEMIS2	2.11
	TICAM1	1.54
Positive regulation of inflammatory response	FFAR3	3.47	CLOCK	−1.14
	GPSM3	2.80	KARS1	−0.62
	GRN	0.78	SNCA	−0.81
	HLA−E	1.52
	NLRP1	1.71
	NLRP12	3.16
	PLCG2	0.85
	RPS19	0.92
Negative regulation of inflammatory response	GRN	0.78	IGF1	−0.95
	MAPK7	1.16	PPARG	−1.20
	MFHAS1	1.44	SOD1	−1.21
	NLRP12	3.16
	RPS19	0.92

DEGs involved in the “Inflammatory response” and its regulation with fold change associated. Fold change was calculated as log₂ (AT-OB/AT-Ctrl). In this line, the upregulated genes were more expressed in AT-OB while downregulated genes were more expressed in AT-Ctrl. The DEG is specified if it is involved in positive or negative regulation. All the values are rounded to the second decimal digit.