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. 2022 Aug 13;14(16):3915. doi: 10.3390/cancers14163915

Figure 1.

Figure 1

Chromosomal localization of FAM107A in PCa, expression characteristics of FAM107A gene, and its correlation with clinical prognosis. (A) FAM107A is located in the short-arm region of chromosome 3. (B) Tissue expression of human FAM107A gene. Distribution of RNA expression of FAM107A gene in normal tissue types. It was created using the transcriptomic dataset of the Human Protein Atlas database. (C) FAM107A protein expression in prostate tissue according to human immunochemistry data on 44 tissues from the Human Protein Atlas project. (D) Prediction of the possible 3D structure of the FAM107A protein according to AlphaFold Monomer v2.0. (E) FAM107A was expressed at lower levels in prostate tumor specimens than normal prostate tissue specimens. GEPIA includes 492 prostate cancer tissue samples and 52 normal prostate tissue samples from the TCGA database, and 100 normal prostate tissue samples from the GTEx database. Overall survival (OS) of patients with prostate cancer according to FAM107A expression (http://gepia.cancer-pku.cn (accessed on 1 June 2022)). (F) FAM107A expression levels were lower in prostate cancer tumor tissues compared to normal prostate tissues in the GSE70768 dataset. (G) FAM107A expression levels were lower in prostate cancer tumor tissues compared to normal prostate tissues in the dataset GSE46602. (H) Kaplan–Meier analysis of overall survival (OS) of prostate cancer patients according to FAM107A expression in the GSE16560 dataset. **** for p < 0.0001, and * for p < 0.05.