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View full-text article in PMC

. 2022 Aug 13;14(16):3915. doi: 10.3390/cancers14163915

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© 2022 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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FAM107A affects PCa cell migration and invasion through FAK/PI3K/AKT pathway. (A,B) AKT activator SC79 partially restores the effect of FAM107A overexpression on cell invasion ability. The number of invading PCa cells was quantified using ImageJ software. (C,D) Effect of AKT activator SC79 partially restores FAM107A overexpression on wound healing assays. Wound healing was quantified using ImageJ software. (E) An immunofluorescence assay was used to detect the expression of Vimentin in each group of cells at a magnification of 400×. (F) Western blotting analysis of changes in key proteins during EMT. (G) Western blotting analysis of changes in key proteins during cell cycle and apoptosis.*** for p < 0.001, and ** for p < 0.01.