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. 2022 Aug 11;13:866252. doi: 10.3389/fendo.2022.866252

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Copyright © 2022 Ding, Wang, Du, Han, Zhang and Zhu

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Proteins of urinary EV with significant difference. A. the proteins in urinary EV significantly upregulated in DN patients compared with healthy control; B1. the proteins in urinary EV significantly upregulated in DN patients compared with healthy control and also showed an increased trend with the progression of DN; B2. the proteins in urinary EV significantly upregulated in DN patients compared with healthy control, whereas showed a decreased trend with the progression of DN; C1. the proteins in urinary EV significantly downregulated in DN patients compared with healthy control, whereas showed an increased trend with the progression of DN; C2. the proteins in urinary EV significantly downregulated in DN patients compared with healthy control and also showed a decreased trend with the progression of DN; D. the proteins in urinary EV significantly downregulated in DN patients compared with healthy control.