Table 1.
Comparison of the variables used in this study among cirrhotics and non-cirrhotics.
| Cirrhotics (79) | Non-Cirrhotics (105) | T (Z); χ2 | |
|---|---|---|---|
| Sex (men/women) | 73/6 | 99/6 | χ2 = 0.04; p = 0.83 (NS) |
| Age (years) | 60.05 ± 9.87 | 58.10 ± 12.20 | T = 1.16; p = 0.25 (NS) |
| Daily ethanol (g) | 194 ± 101 200 (120–243) |
183 ± 146 147 (96–228) |
Z = 1.67; p = 0.10 (NS) |
| Years of addiction | 32 ± 13 | 33 ± 14 | T = 0.37; p = 0.71 (NS) |
| MCV (fL) | 101.14 ± 10.22 100.60 (96.45–104.00) |
99.82 ± 6.17 100.60 (95.30–107.70) |
Z = 0.76; p = 0.45 (NS) |
| GGT (U/L) | 348.53 ± 564.90 197.00 (71.00–390.00) |
209.29 ± 264.31 101.00 (54.00–243.50) |
Z = 2.45; p = 0.014 |
| Klotho (pg/mL) | 967.98 ± 769.34 792.00 (580.60–1192.80) |
533.05 ± 410.11 439.40(289.35–660.64) |
Z = 5.76; p < 0.001 |
| IL-6 (pg/mL) (*) | 14.68 ± 16.02 10.18 (4.08–18.23) |
15.21 ± 23.96 4.85 (0.92–19.64) |
Z = 1.73; p = 0.08 (NS) |
| IL-8 (pg/mL) (**) | 99.30 ± 170.42 40.67 (22.65–100.00) |
49.10 ± 181.98 18.41 (11.36–30.97) |
Z = 4.06; p < 0.001 |
| TNF-α (pg/mL) (***) | 5.27 ± 5.85 5.00 (1.59–5.00) |
7.72 ± 11.97 5.00 (2.75–5.00) |
Z = 1.48; p = 0.14 (NS) |
| CRP (mg/L) (****) | 26.81 ± 38.12 14.40 (4.30–33.00) |
31.04 ± 56.24 11.90 (4.20–33.13) |
Z = 0.22; p = 0.82 (NS) |
| MDA (µmol/L) (*****) | 4.32 ± 4.10 2.92 (1.93–5.30) |
2.75 ± 2.96 1.88 (1.26–2.84) |
Z = 3.93; p < 0.001 |
| Prothrombin activity (%) | 66.37 ± 20.65 66.00 (53.00–83.00) |
87.30 ± 14.08 89.00 (79.00–100.00) |
Z = 6.87; p < 0.001 |
| Albumin (g/dL) | 3.50 ± 0.80 3.50 (3.00–4.00) |
3.76 ± 0.60 3.80 (3.40–4.20) |
T = 2.43; p = 0.016 |
| Bilirubin (mg/dL) | 3.41 ± 4.06 2.00 (1.00–4.20) |
1.33 ± 1.38 1.00 (1.00–2.00) |
Z = 5.88; p < 0.001 |
| Platelet count (/µL) | 136,784 ± 91,302 118,000 (68,000–167,000) |
234,298 ± 116,588 213,000 (149,500–292,500) |
Z = 6.39; p < 0.001 |
| Serum creatinine (mg/dL) | 1.05 ± 0.78 0.80 (0.63–1.10) |
0.84 ± 0.40 0.76 (0.61–0.91) |
Z = 1.32; p = 0.18 (NS) |
Data are given as mean ± standard deviation and as median and (interquartile range) when the variables showed a non-parametric distribution. * n = 150 (66 cirrhotics); ** n = 101 (42 cirrhotics); *** n = 152 (66 cirrhotics); **** n = 179 (77 cirrhotics); ***** n = 171 (70 cirrhotics). Cytokine, MDA, Klotho, cirrhosis, and survival data are shown in the Supplementary Materials.