Table 2.
PanCancer IO 360 Biological Signatures.
| Tumor Signature | Tumor Microenvironment Signature |
Immune Response Signature | |||||
|---|---|---|---|---|---|---|---|
| Tumor Immunogenicity |
Tumor Sensitivity to Immune Attack |
Inhibitory Tumor Mechanisms |
Stromal Factors |
Inhibitory Metabolism |
Inhibitory Immune Signaling |
Anti-TumorImmune Activity |
Immune Cell Population Abundance |
| APM | Apoptosis | B7-H3 | Endothelial Cells | Glycol Act | ARG1 | TIS | B Cells |
| APM Loss | JAK-STAT Loss | IDO1 | Stroma | Hypoxia | CTLA4 | Cytotoxicity | CD45 |
| Hypermutation | Proliferation | PD-L1 | IL10 | IFN Down | CD8 T Cells | ||
| Immunoproteasome | TGF-Beta | Inflam Chemokine | IFN Gamma | Cytotoxic Cells | |||
| MAGEs | Myeloid Inflam | Lymphoid | DC | ||||
| MMR Loss | NOS2 | MHC2 | Exhausted CD8 | ||||
| MSI Predictor | PD-1 | Myeloid | Macrophages | ||||
| PD-L2 | Mast Cells | ||||||
| TIGIT | Neutrophils | ||||||
| NK CD56dim | |||||||
| NK Cells | |||||||
| T Cells | |||||||
| TH1 Cells | |||||||
| Treg | |||||||
Legend: APM = Antigen presenting (or processing) machinery; MAGEs = Melanoma-Associated Antigen Gene Expression; MMR Loss = Mismatch Repair Loss; MSI = Microsatellite Instability; JAK-STAT Loss = JAK-STAT pathway expression loss; B7-H3 = CD276 gene expression; IDO1 = Indoleamine 2,3-dioxygenase 1 gene expression; PD-L1 = Program cell death ligand 1 gene expression; TGF-Beta = Transforming Growth Factor Beta gene expression; ARG1 = Arginase-1 gene expression; CTLA4 = Cytotoxic T-lymphocyte-associated protein 4 gene expression; IL10 = Interleukin-10 gene expression; NOS2 = Nitric Oxide Synthase 2 gene expression; PD-1 = Program cell death receptor 1 gene expression; PD-L2 = Program cell death ligand 2 gene expression; TIGIT = T cell immunoreceptor and Ig and ITIMS gene expression; TIS = Tumor Inflammation Signature, TIS measures the abundance of a peripherally suppressed adaptive immune response within the tumor; IFN Down = Interferon Signaling Response; IFN Gamma = Interferon gamma signaling; MHC2 = Major histocompatibility complex class II antigen presentation; DC = Dendritic cell abundance; NK = Natural Killer; TH1 Cells = T-box transcription factor TBX21 (T-bet) expressing cell abundance; Treg = Regulatory T cell abundance.