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. 2022 Jul 27;12(8):1038. doi: 10.3390/biom12081038

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© 2022 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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Comparison of nucleosome markers and derived ratio calculation according to APACHE-II and SOFA scores in septic shock and critical COVID-19 subjects. Boxes represent 25th–75th percentile with median. Whiskers represent min to max variation. Squares represent patients with a thromboembolic event, and non-transparent symbols represent dead patients. *, **, *** and **** represent p-values ≤ 0.05, ≤0.01, ≤0.001 and ≤0.0001, respectively. Only differences that are statistically significant are reported. Abbreviations: Cit-H3, citrullinated histone H3 (citrullinated in R2, R8 and R17); MPO, myeloperoxidase; NE, neutrophil elastase; Nu.Cit-H3R8, citrullinated H3R8-nucleosome; Nu.H3.1, H3.1-nucleosome.