Table 1.
Non-AD | AD | p Value | |
---|---|---|---|
Gender (males/females) | 16 (7/9) | 10 (5/5) | NS 1 |
Age (years) | 67.0 ± 12.3 | 68.5 ± 16.1 | NS 2 |
Disease Duration (years) | 2.96 ± 1.27 | 3.88 ± 2.50 | NS 2 |
MMSE | 23.3 ± 8.50 | 15.5 ± 8.80 | 0.034 2 |
Serum τP-181 (pg/mL) | 2.16 ± 1.77 | 3.01 ± 0.83 | NS 2 |
CSF Aβ (z-score) | −0.49 ± 1.52 | −1.63 ± 1.21 | 0.056 2 |
CSF τP-181 (z-score) | 0.11 ± 0.92 | 3.51 ± 2.48 | <0.0001 2 |
CSF τΤ (z-score) | 0.25 ± 1.12 | 2.53 ± 2.47 | 0.004 2 |
Results are presented as mean ± standard deviation. AD: Alzheimer’s Disease, MMSE: Mini Mental State Examination, CSF: Cerebrospinal fluid, Aβ: either Aβ42/Aβ40 or Aβ42 alone (when Aβ40 was not available), τP-181: tau protein phosphorylated at a threonine residue at position 181, τΤ: total tau protein, NS: non-significant. 1 χ2-test, 2 t-test.