. 2022 Aug 10;12(8):1099. doi: 10.3390/biom12081099

Table 4.

Receiver Operating Characteristics (ROC) analysis of the discriminant value for each of the studied biomarkers.

Biomarker	AUC	Cut-Off Value	Sensitivity	Specificity	p Value
Plasma τ_P-181 (pg/mL)	0.83	2.80	1.00	0.75	<0.0001
Plasma τ_P-181 (pg/mL)	(0.67–0.93)	2.80	(0.74–1.00)	(0.53–0.90)	<0.0001
Serum τ_P-181 (pg/mL)	0.72	1.94	0.90	0.63	0.034
Serum τ_P-181 (pg/mL)	(0.51–0.88)	1.94	(0.56–0.98)	(0.35–0.85)	0.034
CSF Aβ (z-score)	0.82	–1.27	0.80	0.79	0.0001
CSF Aβ (z-score)	(0.63–0.93)	–1.27	(0.44–0.98)	(0.54–0.94)	0.0001
CSF τ_P-181 (z-score)	0.94 *	0.77	1.00	0.74	<0.0001
CSF τ_P-181 (z-score)	(0.78–0.99)	0.77	(0.69–1.00)	(0.49–0.91)	<0.0001
CSF τ_T (z-score)	0.87	0.98	0.80	0.84	<0.0001
CSF τ_T (z-score)	(0.69–0.96)	0.98	(0.44–0.98)	(0.60–0.97)	<0.0001

AUC: Area under the ROC curve. p values indicate the level of significance as compared to an AUC of 0.5. Values in parentheses indicate the 95% confidence interval. * p = 0.04 vs. serum τ_P-181.