Figure 6.

Effect of um-PEA on peripheral neuropathy in presence of CB1 or PPAR-α antagonists. Results of the (A) von Frey test to evaluate mechanical allodynia; (B) Randall–Selitto test to assess mechanical hyperalgesia; (C) Hargreaves test to evaluate thermal hyperalgesia; ^# p < 0.05 and ^## p < 0.01 versus PTX+um-PEA; ° p < 0.05 versus PTX-vehicle group. Data are presented as mean ± SEM (n = 8). Differences were evaluated by ANOVA followed by Bonferroni’s post hoc test for multiple comparisons.