Table 1.

Differential expression profiling of exosomal noncoding RNAs in ischemic stroke.

Models and Tissues	Detection Method	Changes of Expression Profiles	Focal ncRNAs	Reference
Exosomes from peripheral serum in stroke patients	RNA-Seq and qRT-PCR	1096 lncRNAs covering 307 showed elevated expression while 789 showed decline	lnc-CRKL-2 and lnc-NTRK3-4 ↑ RPS6KA2-AS1 and lnc-CALM1-7 ↓	Xu [16]
Exosomes from peripheral plasma in stroke patients	HTS and qRT-PCR	1020 lncRNAs were differentially expressed, 226 lncRNAs increased and 794 lncRNAs decreased levels	Most: novel lnc_000288 ↑; novel lnc_000285 ↓ lnc_002015/hsa-mir342/PTPRC/AAMP; lnc001350/hsa-mir-3127/ST14	Zhang [17]
Exosomes from peripheral plasma in stroke patients	RNA-Seq and qRT-PCR	319 lncRNAs including 97 increased expression and 222 showed reduction	lnc_000048, lnc_001350 and lnc_016442 ↑ lnc_002015 ↓	Zhang [18]
Exosomes from peripheral plasma in stroke patients	HTS	3540 circRNAs, 1177 increased expression and 2363 decrease expression	/	Xu [19]
Exosomes from peripheral plasma in stroke patients	RNA-Seq and qRT-PCR	25 circRNAs, 9 circRNAs were significantly upregulated and 16 circRNAs were significantly downregulated	hsa_circ_0000698/hsa_circ_0002775/hsa_circ_0005585/hsa_circ_0043837 ↓; hsa-miR-16 ↑; VWF ↓; novel_circ_0010155 ↓; hsa-miR-939 ↑; septin 9 and MYLK2 ↓	Xiao [20]
Exosomes from peripheral plasma in stroke patients	RNA-Seq and qRT-PCR	26 circRNAs, 7 circRNAs were significantly upregulated and 19 circRNAs were significantly downregulated	circ_0043837 circ_0001801	Xiao [21]

↑ upregulation; ↓ downregulation.