Figure 4.

Relation of $sPS$ with structural characteristics in KEGG network. (a) Relation to the degree. Y-axis values mean the correlation coefficients between $sPS$ and the number of nodes’ degree, in-degree, and out-degree. (b) Relation to the involvement of feedback loops. All genes were classified into ‘FBL’ and ‘No FBL’ groups, where a gene involves any feedback loops or not, respectively. Y-axis values mean the average of $sPS$ values. (c) Relations to the centrality measures such as betweenness, stress, closeness, and eigenvector. Y-axis values mean the correlation coefficients between $sPS$ and each centrality measure. Mutation duration time $T$ was set to 14–20.